The Hu Lab is an immunology and chemical biology research group studying one of the most fascinating challenges in biology: how the immune system learns when to attack and when to stay quiet?

We investigate how regulatory T cells (Tregs), T cell anergy, and tolerogenic antigen-presenting cells shape immune responses in cancer, autoimmune disease, transplantation, and reproductive health. By uncovering the molecular logic that restrains immune responses in these settings, we aim to reveal fundamental principles of immune regulation and open new paths for therapy.

Our long-term goal is to turn these discoveries into next-generation immunotherapies. By combining immunology, genetics, chemical biology, and translational disease models, we seek to identify and precisely target the pathways that drive pathological immune suppression, restore immune balance, and create therapies that are more effective, more selective, and safer for patients.

The Hu Lab is part of the Department of Immunobiology, and the Institute of Biomolecular Design and Discovery at Yale University.